کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10747128 | 1048894 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of low estrogen on neurons in the preoptic area of hypothalamus of ovariectomized rats
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کلمات کلیدی
LPODMHMPAc-fosOVXovariectomizedBLAVMpoperitrigeminal nucleusLPBVLPOMNPOCeA - CEAPOAH - خیرSham - شامsham-operated - شام کار می کندLateral preoptic area - منطقه دایره ای جانبیmedial preoptic area - منطقه پیشوپتیک مدیاOvariectomized rats - موش های صحراییVentrolateral preoptic nucleus - هسته preoptic Ventrolateralcentral amygdaloid nucleus - هسته مرکزی amygdaloiddorsomedial hypothalamic nucleus - هسته هیپوتالاموس dorsomediallateral parabrachial nucleus - هسته پاراباژیال جانبی جانبیmedian preoptic nucleus - هسته پیشوپتیک مدیاست
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The purpose of this study was to investigate the difference in neuronal activity in the preoptic area of the hypothalamus (POAH) under low estrogen condition induced by ovariectomy. One hundred and twenty sham-operated (SHAM) and ovariectomized (OVX) rats were placed in different temperatures for 2 h. Twelve rats from each group were stimulated by 4 °C, 10 °C, 25 °C, 33 °C and 38 °C, respectively. c-Fos expression in the POAH was detected by immunohistochemistry. Following exposure to warm and cold stimuli, there were markedly lower c-Fos-positive cell densities in the OVX group compared with the SHAM group in the median preoptic nucleus (MnPO) at 4 °C, 10 °C, 33 °C and 38 °C, in the medial preoptic area (MPA) at 25 °C and 38 °C, in the ventromedial preoptic nucleus (VMPO) at 4 °C, 10 °C and 38 °C and in the ventrolateral preoptic nucleus (VLPO) at 4 °C and 38 °C. Both temperature and surgery had an impact on c-Fos expression by two-way ANOVA method except in the lateral preoptic area (LPO). c-Fos expression differed within different nuclei of the two groups in the same and different temperature stimuli. This indicated that the temperature-sensitive nuclei in the POAH exhibited lower and different activities during temperature stimuli following ovariectomy, which possibly resulted in abnormal thermoregulation and menopausal symptoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 116, Issue 8, October 2014, Pages 1259-1269
Journal: Acta Histochemica - Volume 116, Issue 8, October 2014, Pages 1259-1269
نویسندگان
Wenjuan Wang, Zhiyuan Wang, Wenpei Bai, Hui Zhang, Xiaoyan Ma, Mukun Yang, Ke Wang, Sainan Zhu, Jing Jia, Lihua Qin,