کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10747505 | 1048972 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development
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کلمات کلیدی
ADAMTS-1DRGOdontoblastsIVMdorsal root ganglion - گانگلیون ریشه پشتیstratum granulosum - granulosum stratumAorta - آئورت dorsal aorta - آئورت پشتیAdrenal - آدرنالLingual epithelium - اپیتلیوم لاتینVentricle - بطن چپVent - تهویهDevelopment - رشدBlood vessel - رگ خونیsmooth muscle - عضله صاف Cortex - قشرLamina propria - لامینا پروپریاStratum corneum - لایه شاخی، استراتوم کورنئومRat - موش صحراییTrachea - نای dental papilla - پاپ دندان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development](/preview/png/10747505.png)
چکیده انگلیسی
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-1) belongs to the large ADAM family of proteins. ADAMTS-1 contains a metalloproteinase domain, a disintegrin domain and three thrombospondin-like repeats but unlike ADAMs lacks a transmembrane domain. For the elucidation of the biological functions of ADAMTS-1, we raised new antibodies against ADAMTS-1. We show an accumulation of ADAMTS-1 protein at the basal lamina of rat embryonal epithelia of intestines, nasal cavity, choroid plexus, skin and in intracellular storage vesicles of epithelial cells. ADAMTS-1 protein seems to play a role in the development of the neuronal system, adipose tissue, muscle, heart, liver and adrenal glands. At the time of birth its presence is reduced in most organs. However, in the developing bone as well as in the skin, labelling increased towards late embryonal development. Immunoblots revealed a strong presence of a 62Â kDa ADAMTS-1 fragment in kidneys, adrenal glands, lungs, intestines and heart. ADAMTS-1 was also present in the corresponding adult rat organs, but in more restricted distribution patterns. It was typically found in principal cells of collecting ducts, of the renal medulla, in ependymal cells of the ventricles and in some neurons. The results were confirmed by real-time PCR. The specific distribution pattern of ADAMTS-1 in a variety of organs during embryogenesis suggests a role of the molecule in tissue remodelling, vasculogenesis and angiogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 107, Issue 2, 1 July 2005, Pages 121-131
Journal: Acta Histochemica - Volume 107, Issue 2, 1 July 2005, Pages 121-131
نویسندگان
Willy Günther, Kai-Ove Skaftnesmo, Hans Arnold, Rolf Bjerkvig, A. Jorge A. Terzis,