Serum level and prognostic value of neopterin in patients after ischemic stroke

► Serum neopterin level was notably increased after acute ischemic stroke (IS). ► Serum neopterin level predicted severity of extra-cranial carotid artery stenosis. ► Serum neopterin level independently predicted NIHSS ≥ 12 at 48 h after acute IS. ► Neopterin level independently predicted 90-day major adverse clinical outcome.