Protease profiling of different biofluids in type 1 diabetes mellitus

► We evaluated proteolytic events underlying type 1 diabetes and related complication through zymography. ► Urine and saliva can be useful for the monitoring of type-1 diabetes-related proteolytic events. ► Aminopeptidase N, azurocidin and kallikrein 1 can be targets for type 1 diabetes‐related complications.