Combinative analysis of factors influence serum alanine aminotransferase activity in adult male population from southern China

► Strict criteria was performed to evaluate factors associated with ALT activity. ► Prevalence NAFLD was positive correlated to MetS followed with ALT elevation. ► Obesity and hyperlipidemia were associated with ALT elevation in various models. ► An epidemiology model was imported to evaluate synergic effect on ALT. ► No synergic effect was found between virological factor and MetS on ALT.