Development of an HPLC method for monitoring of Photofrin II therapy

The method described here will enable large-scale clinical pharmacokinetic studies on Photofrin II; investigations can now address possible correlations between individual concentrations of drug-derived plasma porphyrins and systemic photosensitivity-representing the main side effect of Photofrin II-with the perspective of individualized light protection regimens after Photofrin II administration.