کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10819394 | 1060382 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of nitric oxide in 5-hydroxytryptamine-, cholera toxin-, enterotoxigenic Escherichia coli- and Salmonella Typhimurium-induced secretion in the porcine small intestine
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کلمات کلیدی
5-HTSPI-1NOS-2PMNsiNOSNOSETECCOX-2STAE. coliCFU5-hydroxytryptamine, serotonin - 5-hydroxytryptamine، serotoninenterotoxigenic Escherichia coli - Esterichia coli Enterotoxigenicl-NAME - L-NAMENω-nitro-l-arginine methyl ester - N-Nitro-L-Arginine Methyl EsterNO2− - NO2-NO3− - NO3-Escherichia coli - اشریشیا کُلیinflammation - التهاب( توروم) heat-labile enterotoxin - انتروتوکسین گرم لابلیIntestinal secretion - ترشح رودهSalmonella Pathogenicity Island 1 - جزیره پاتوژنز سالمونلا 1Swine - خوکSalmonella - سالمونلاSerotonin - سروتونینinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییcholera toxin - سوزش گوارشیCyclooxygenase-2 - سیکلوکوکسیژناز2Physiopathology - فیزیوپاتولوژیpolymorphonuclear leukocytes - لکوسیت های پلی مورفونیک هسته ایNitrate - نیتراتNitrite - نیتریتNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازNitric oxide synthase-2 - نیتریک اکسید سنتاز-2STB - و غیره.colony-forming unit - واحد تشکیل کلنی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of nitric oxide in 5-hydroxytryptamine-, cholera toxin-, enterotoxigenic Escherichia coli- and Salmonella Typhimurium-induced secretion in the porcine small intestine Effects of nitric oxide in 5-hydroxytryptamine-, cholera toxin-, enterotoxigenic Escherichia coli- and Salmonella Typhimurium-induced secretion in the porcine small intestine](/preview/png/10819394.png)
چکیده انگلیسی
The effects of nitric oxide (NO) in the secretory response to the endogenous secretagogue 5-hydroxytryptamine (5-HT), the enterotoxins heat-labile enterotoxigenic Escherichia coli (ETEC) toxin (LT) and cholera toxin (CT), and various cultures of ETEC and Salmonella serotype Typhimurium in the porcine small intestine (Sus scrofa) were investigated. In anaesthetized pigs, jejunal tied-off loops were instilled with 5-HT, LT, CT, various cultures of ETEC or S. Typhimurium. Pigs were given intravenously isotonic saline or isotonic saline containing the NO synthase inhibitor, NÏ-nitro-l-arginine methyl ester (L-NAME). L-NAME significantly induced an increased fluid accumulation in loops induced by 5-HT, ETEC and stn-mutated S. Typhimurium. Fluid accumulation in loops instilled with wild-type S. Typhimurium was increased by L-NAME, although not significantly, while there was no effect on fluid accumulation induced by an invH-mutated isogenic strain. No significant effect of L-NAME was observed on the fluid accumulation induced by the purified enterotoxins LT and CT. The results also demonstrated a relatively large difference in the ability to induce fluid accumulation between the bacteria strains. Diastolic, systolic and mean blood pressures were significantly increased and the body temperature was significantly decreased in groups of pigs treated with L-NAME. In conclusion, the results suggest that NO has a proabsorptive effect in the intact porcine jejunum and is involved in the systemic vascular tone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 141, Issue 4, August 2005, Pages 476-484
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 141, Issue 4, August 2005, Pages 476-484
نویسندگان
Marie Louise Grøndahl, Martin Andreas Unmack, Helga Berglind Ragnarsdóttir, Mark Berner Hansen, John Elmerdahl Olsen, Erik Skadhauge,