کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10825316 | 1063594 | 2005 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The distribution and cellular localization of glutamic acid decarboxylase-65 (GAD65) mRNA in the forebrain and midbrain of domestic chick
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کلمات کلیدی
INPfield LsRTFRLSPABSTLPTMTRNtNAArcopalliumNidopalliumMesopalliumGCTTPOGLDCDLSCVTEOEntopalliumHyperpalliumArcopallium intermediumSubstantia grisea centralisnucleus ovoidalisnucleus mesencephalicus lateralis, pars dorsalisnucleus pretectalisnucleus geniculatus lateralis, pars ventralisnucleus isthmi, pars magnocellularisMSTSPMRPOMLDSPLDTZSNRPOAPTCLSTIMCPTSLFBSCEHabenula - habenulaVentral pallidum - pallidum درشتSubstantia Nigra, pars reticulata - Substantia Nigra، pars reticulataArco - آرکوALP - آلکالن فسفاتازStriatum - استریاتومMedial striatum - استریاتومیکVentricle - بطن چپTuberculum olfactorium - توبرکل بویاییsubpallium - زیرمجموعهOptic tectum - سقف نوریbasal ganglia - عقدههای قاعدهایPVN - مالیات بر ارزش افزودهChick brain - مغز جوجهNucleus accumbens - هسته accumbensThalamic reticular nucleus - هسته reticular توالیومNucleus rotundus - هسته rotundusparaventricular nucleus - هسته پروژسترویکHypothalamus - هیپوتالاموسHippocampus - هیپوکامپ nucleus reticularis pontis oralis - پل دهان هستهolfactory bulb - پیاز بویاییGABA - گاباGlv - گلوGlobus pallidus - گوی رنگ پریده، گلوبوس پالیدوس
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The distribution and cellular localization of GAD65 mRNA in the forebrain and midbrain of domestic chick were examined by in situ hybridization histochemistry with 35[S]-UTP labeled cRNA probes, using film and emulsion autoradiography. Film autoradiograms showed intense GAD65 labeling in many structures of the basal telencephalon, such as the medial and lateral striatum, the septum, the olfactory tubercle, the lateral bed nucleus of the stria terminalis, and the intrapeduncular nucleus, while the pallial telencephalon showed only a low level of labeling. Emulsion-coated sections revealed that GAD65 mRNA-containing neurons were at least six times more abundant in striatum than pallium, with only a uniformly scattered subpopulation labeled in pallium, and that the vast majority of the large scattered projection neurons of globus pallidus were heavily labeled for GAD65. Prominent labeling was also evident in the nucleus taeniae and subpallial amygdala, but not in the arcopallium in film autoradiograms. Within the diencephalon, the hypothalamus was more GAD65-rich than the thalamus. Additional subtelencephalic cell groups showing prominent labeling included the thalamic reticular nucleus and ventral lateral geniculate nucleus of the diencephalon, the nucleus pretectalis, subpretectalis and spiriformis lateralis of the pretectum, and the magnocellular isthmic nucleus of the optic lobe. Tectal layers 9-10 were also rich in GAD65. These results further clarify GABAergic circuits of the avian forebrain and midbrain, and show them to closely resemble those in mammals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chemical Neuroanatomy - Volume 29, Issue 4, June 2005, Pages 265-281
Journal: Journal of Chemical Neuroanatomy - Volume 29, Issue 4, June 2005, Pages 265-281
نویسندگان
Z. Sun, H.B. Wang, A. Laverghetta, K. Yamamoto, A. Reiner,