The Singaporean English and Chinese versions of the EQ-5D achieved measurement equivalence in cancer patients

ObjectiveTo assess measurement equivalence of the Singaporean English and Chinese versions of the EuroQol Group's 5-domain questionnaire (EQ-5D) in cancer patients.Study Design and SettingSeven hundred and seventy-one ethnic Chinese patients in Singapore were recruited, and they answered either an English or a Chinese version of the EQ-5D. Seven days later, a similar questionnaire in the same language was mailed to the patients. Regression analysis was used to assess equivalence of the mean values obtained by using the two language versions. The validity, responsiveness to change, and reliability of the two versions of the EQ-5D were assessed and compared.ResultsBased on the prespecified equivalence margin of ±10% for binary outcome, ±0.05 for utility index, and ±5 points in the visual analog scale, the two language versions of the EQ-5D gave equivalent mean values at item and scale levels. They also showed similar characteristics in validity, responsiveness, and reliability. For example, the test–retest reliability values for the EQ-5D utility index in the two language samples were identical in two significant digits: 0.79.ConclusionThe Singaporean English and Chinese versions of the EQ-5D were validated in cancer patients and were shown to achieve measurement equivalence.