The retinal renin-angiotensin system: Roles of angiotensin II and aldosterone

► Components of the renin-angiotensin system are expressed in both vascular and neuroglial cells. ► Angiotensin receptor and ACE blockade reduces vascular and neuroglial injury in retinopathy. ► A local aldosterone/mineralocorticoid system exists in the retina. ► Aldosterone may influence vascular pathology and glia and ganglion cell function in the retina.