کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10836153 | 1066405 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nociceptin/orphanin FQ inhibits electrically induced contractions of the human bronchus via NOP receptor activation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Nociceptin/orphanin FQ inhibits electrically induced contractions of the human bronchus via NOP receptor activation Nociceptin/orphanin FQ inhibits electrically induced contractions of the human bronchus via NOP receptor activation](/preview/png/10836153.png)
چکیده انگلیسی
Nociceptin/orphanin FQ (N/OFQ) has been reported to inhibit neurogenic contractions in various tissues, including guinea pig airways. In the present study, we investigated the ability of N/OFQ to affect cholinergic contractions of human bronchi elicited by electrical field stimulation (EFS). Tissues were obtained from 23 patients undergoing surgery for lung cancer. EFS (20 Hz, 320 mA, 1.5 ms, 10 s) was applied five times every 20 min. Contractions induced by EFS were abolished by either TTX (1 μM) or atropine (1 μM) and concentration-dependently (10 nM-1 μM) inhibited by N/OFQ (Emax, 11.5 ± 1.8% inhibition). The inhibitory effects of N/OFQ were mimicked by the N/OFQ receptor (NOP) ligand [Arg14, Lys15]N/OFQ which displayed however, higher significant maximal effects (17.7 ± 2.9% inhibition, P < 0.05). The actions of N/OFQ and [Arg14, Lys15]N/OFQ were not affected by naloxone (1 μM) while prevented by the selective NOP receptor antagonist UFP-101 (10 μM). Moreover, the inhibitory effects of NOP agonists were no longer evident in tissues treated with tertiapin (10 μM), an inhibitor of inward-rectifier potassium channels. In conclusion, the present data demonstrate that N/OFQ inhibited acetylcholine (ACh) release in the human bronchi via NOP receptor activation. This effect may involve stimulation of potassium currents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 26, Issue 8, August 2005, Pages 1492-1496
Journal: Peptides - Volume 26, Issue 8, August 2005, Pages 1492-1496
نویسندگان
Marco Basso, Paul André Risse, Emmanuel Naline, Girolamo Calo, Remo Guerrini, Domenico Regoli, Charles Advenier,