کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10847855 1070485 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New unusual pregnane glycosides with antiproliferative activity from Solenostemma argel
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
New unusual pregnane glycosides with antiproliferative activity from Solenostemma argel
چکیده انگلیسی
Seven new 15-keto pregnane glycosides, namely Stemmosides E-K, were isolated from Solenostemma argel. Stemmosides E-J are characterized by the occurrence of an uncommon 14β proton configuration while stemmosides E and F possess in addition a rare enolic function in C-16. On the other hand, stemmosides G-J display an unusual C-17α side chain. Their structures were established by ESI-MS and NMR experiments. Moreover, the effect of these compounds on the VEGF-induced in Kaposi's sarcoma cell proliferation was tested. Results indicated that all the compounds reduced the cell proliferation in a dose dependent manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 70, Issue 9, August 2005, Pages 594-603
نویسندگان
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