کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10848093 1070538 2012 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of multiply deuterated 3- and 21-monosulfates of allo-tetrahydrocorticosteroids as internal standards for mass spectrometry
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Synthesis of multiply deuterated 3- and 21-monosulfates of allo-tetrahydrocorticosteroids as internal standards for mass spectrometry
چکیده انگلیسی
► We synthesized the 3- and 21-monosulfates of multiply deuterated 5α-tetrahydrocorticosteroids. ► Exchange reaction of the 5α-3- or -11-ketosteroids with NaOD in MeOD followed by NaBD4 was employed. ► 3β-Hydroxy group was epimerized into 3α configuration by Walden inversion. ► Sulfation of C-3 and C-21 hydroxy groups was attained by treatment with SO3-TMA complex. ► The isotopic purity of labeled compound was enough high to use them as a internal standard in LC/MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 77, Issue 13, November 2012, Pages 1423-1437
نویسندگان
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