Divide Et Impera-cellular auxin compartmentalization

► PIN5, PIN8, PILS2 and PILS5 are putative auxin carriers at the ER. ► Intracellular auxin transport compartmentalizes auxin. ► Intracellular auxin transport affects nuclear auxin signaling. ► PIN5, PIN8, PILS2 and PILS5 activity affect auxin metabolism. ► PIN and PILS proteins are evolutionary distinct.