کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10869804 1073971 2015 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Integration of PKR-dependent translation inhibition with innate immunity is required for a coordinated anti-viral response
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Integration of PKR-dependent translation inhibition with innate immunity is required for a coordinated anti-viral response
چکیده انگلیسی
Viral triggering of the innate immune response in infected cells aims at delaying viral replication and prevents tissue spreading. Viral replication is delayed by host protein synthesis inhibition and infected cell apoptosis on one hand, while infection spreading is controlled by the synthesis of specific proteins like type‐I interferons (IFNs) and pro‐inflammatory cytokines on the other hand. How do these two apparent conflicting responses cooperate within the same infected cells to mount effective defenses against pathogens? What are the molecules or the complexes resolving this contradiction over time? Some recent studies reveal unanticipated connections between innate immunity and stress pathways, giving important clues on how the cellular responses are orchestrated to limit infection efficiently.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 14, 22 June 2015, Pages 1539-1545
نویسندگان
, , ,