کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10869849 | 1073974 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A brief review of nucleosome structure
ترجمه فارسی عنوان
بررسی مختصر ساختار هسته ای
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کلمات کلیدی
ساختار هسته ای، هیستون، ساختار کروماتین،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
چکیده انگلیسی
The nucleosomal subunit organization of chromatin provides a multitude of functions. Nucleosomes elicit an initial â¼7-fold linear compaction of genomic DNA. They provide a critical mechanism for stable repression of genes and other DNA-dependent activities by restricting binding of trans-acting factors to cognate DNA sequences. Conversely they are engineered to be nearly meta-stable and disassembled (and reassembled) in a facile manner to allow rapid access to the underlying DNA during processes such as transcription, replication and DNA repair. Nucleosomes protect the genome from DNA damaging agents and provide a lattice onto which a myriad of epigenetic signals are deposited. Moreover, vast strings of nucleosomes provide a framework for assembly of the chromatin fiber and higher-order chromatin structures. Thus, in order to provide a foundation for understanding these functions, we present a review of the basic elements of nucleosome structure and stability, including the association of linker histones.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 20, Part A, 7 October 2015, Pages 2914-2922
Journal: FEBS Letters - Volume 589, Issue 20, Part A, 7 October 2015, Pages 2914-2922
نویسندگان
Amber R. Cutter, Jeffrey J. Hayes,