کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10869941 1073980 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The multifaceted roles of intrinsic disorder in protein complexes
ترجمه فارسی عنوان
نقش چندوجهی اختلال ذاتی در پروتئین ها
کلمات کلیدی
پروتئین ناسازگار ذاتی منطقه پروتئینی ناسازگار ذاتی، پروتئین تعامل پروتئین، پروتئین پیچیده، داربست، مقررات، تعامل مولکولی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
چکیده انگلیسی
Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) are important constituents of many protein complexes, playing various structural, functional, and regulatory roles. In such disorder-based protein complexes, functional disorder is used both internally (for assembly, movement, and functional regulation of the different parts of a given complex) and externally (for interactions of a complex with its external regulators). In complex assembly, IDPs/IDPRs serve as the molecular glue that cements complexes or as highly flexible scaffolds. Disorder defines the order of complex assembly and the ability of a protein to be involved in polyvalent interactions. It is at the heart of various binding mechanisms and interaction modes ascribed to IDPs. Disorder in protein complexes is related to multifarious applications of induced folding and induced functional unfolding, or defines the entropic chain activities, such as stochastic machines and binding rheostats. This review opens a FEBS Letters Special Issue on Dynamics, Flexibility, and Intrinsic Disorder in protein assemblies and represents a brief overview of intricate roles played by IDPs and IDPRs in various aspects of protein complexes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 19, Part A, 14 September 2015, Pages 2498-2506
نویسندگان
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