کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10869979 1073983 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells
چکیده انگلیسی
Hepatitis B virus (HBV) replication is controlled by liver-enriched transcriptional factors, including forkhead box protein A (FOXA) members. Here, we found that FOXA members are directly and indirectly involved in HBV replication in human hepatic cells. HBV replication was elevated in HuH-7 treated with individual FOXA members-specific siRNA. Reciprocally, the downregulation of HBV replication was observed in FOXA-induced HuH-7. However, the mechanism of downregulation is different among FOXA members at the level of HBV RNA transcription, such as precore/pg RNA and 2.1 kb RNA. In addition, FOXA1 and FOXA2 suppressed nuclear hormone receptors, such as HNF4α, that are related to HBV replication.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 10, 28 April 2015, Pages 1112-1118
نویسندگان
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