کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870059 1073988 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein folding of the SAP domain, a naturally occurring two-helix bundle
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Protein folding of the SAP domain, a naturally occurring two-helix bundle
چکیده انگلیسی
The SAP domain from the Saccharomyces cerevisiae Tho1 protein is comprised of just two helices and a hydrophobic core and is one of the smallest proteins whose folding has been characterised. Φ-value analysis revealed that Tho1 SAP folds through a transition state where helix 1 is the most extensively formed element of secondary structure and flickering native-like core contacts from Leu35 are also present. The contacts that contribute most to native state stability of Tho1 SAP are not formed in the transition state.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 15, 8 July 2015, Pages 1740-1747
نویسندگان
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