کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10870169 | 1073992 | 2014 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MicroRNAs function as cis- and trans-acting modulators of peripheral circadian clocks
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: MicroRNAs function as cis- and trans-acting modulators of peripheral circadian clocks MicroRNAs function as cis- and trans-acting modulators of peripheral circadian clocks](/preview/png/10870169.png)
چکیده انگلیسی
Based on their extracellular expression and targeting of the clock gene Bmal1, miR-142-3p and miR-494 were analyzed for evidence of vesicle-mediated communication between cells and intracellular functional activity. Our studies demonstrate that: miR-142-3p + miR-494 overexpression decreases endogenous BMAL1 levels, increases the period of Per2 oscillations, and increases extracellular miR-142-3p/miR-494 abundance in conditioned medium; miRNA-enriched medium increases intracellular expression of miR-142-3p and represses Bmal1 3â²-UTR activity in naïve cells; and inhibitors of vesicular trafficking modulate intercellular communication of these miRNAs and ensemble Per2 rhythms. Thus, miR-142-3p and miR-494 may function as cis- and trans-acting signals contributing to local temporal coordination of cell-autonomous circadian clocks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 17, 25 August 2014, Pages 3015-3022
Journal: FEBS Letters - Volume 588, Issue 17, 25 August 2014, Pages 3015-3022
نویسندگان
Vikram R. Shende, Sam-Moon Kim, Nichole Neuendorff, David J. Earnest,