کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870297 1073997 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural and functional characterization of tumor suppressors TIG3 and H-REV107
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Structural and functional characterization of tumor suppressors TIG3 and H-REV107
چکیده انگلیسی
H-REV107-like family proteins TIG3 and H-REV107 are class II tumor suppressors. Here we report that the C-terminal domains (CTDs) of TIG3 and H-REV107 can induce HeLa cell death independently. The N-terminal domain (NTD) of TIG3 enhances the cell death inducing ability of CTD, while NTD of H-REV107 plays an inhibitory role. The solution structure of TIG3 NTD is very similar to that of H-REV107 in overall fold. However, the CTD binding regions on NTD are different between TIG3 and H-REV107, which may explain their functional difference. As a result, the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 11, 8 May 2015, Pages 1179-1186
نویسندگان
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