کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870462 1074002 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
miR-10a controls glioma migration and invasion through regulating epithelial-mesenchymal transition via EphA8
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
miR-10a controls glioma migration and invasion through regulating epithelial-mesenchymal transition via EphA8
چکیده انگلیسی
MicroRNAs (miRNAs) play a critical role in the development of cancers. However, the role of miRNAs in glioma is still poorly understood. In this study, we demonstrate that microRNA-10a (miR-10a) promotes cell migration and invasion by negatively regulating the expression of Eph tyrosine kinase receptor A8 (EphA8). Ectopic expression of EphA8 counteracts the promotion of migration and invasion induced by miR-10a. We further demonstrate that miR-10a and EphA8 regulate epithelial-mesenchymal transition (EMT) to affect cell migration and invasion. Collectively, we unveil a branch of the miR-10a/EphA8 pathway that regulates the progression of glioma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 6, 12 March 2015, Pages 756-765
نویسندگان
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