کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870491 1074008 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Crystal structure of the RNA demethylase ALKBH5 from zebrafish
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Crystal structure of the RNA demethylase ALKBH5 from zebrafish
چکیده انگلیسی
ALKBH5, a member of AlkB family proteins, has been reported as a mammalian N6-methyladenosine (m6A) RNA demethylase. Here we report the crystal structure of zebrafish ALKBH5 (fALKBH5) with the resolution of 1.65 Å. Structural superimposition shows that fALKBH5 is comprised of a conserved jelly-roll motif. However, it possesses a loop that interferes potential binding of a duplex nucleic acid substrate, suggesting an important role in substrate selection. In addition, several active site residues are different between the two known m6A RNA demethylases, ALKBH5 and FTO, which may result in their slightly different pathways of m6A demethylation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 6, 18 March 2014, Pages 892-898
نویسندگان
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