کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870594 1074014 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Saturated fatty acid-induced miR-195 impairs insulin signaling and glycogen metabolism in HepG2 cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Saturated fatty acid-induced miR-195 impairs insulin signaling and glycogen metabolism in HepG2 cells
چکیده انگلیسی
MicroRNAs (miRNAs) play an important role in insulin signaling and insulin secretion, but the role of miRNAs in the association between obesity and hepatic insulin resistance is largely unknown. This study reports that saturated fatty acid (SFA) and high fat diet (HFD) significantly induce miR-195 expression in hepatocytes, and that the insulin receptor (INSR), not insulin receptor substrate-1 (IRS-1), is a direct target of miR-195. Furthermore, the ectopic expression of miR-195 suppresses the expression of INSR, thereby impairing the insulin signaling cascade and glycogen synthesis in HepG2 cells. These findings suggest that the dysregulation of miR-195 by SFA is a detrimental factor for hepatic insulin sensitivity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 21, 3 November 2014, Pages 3939-3946
نویسندگان
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