کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870597 1074014 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential contribution of the Fanconi anemia-related proteins to repair of several types of DNA damage in cultured silkworm cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Differential contribution of the Fanconi anemia-related proteins to repair of several types of DNA damage in cultured silkworm cells
چکیده انگلیسی
The silkworm Fanconi anemia (FA) pathway is required for normal cellular resistance to mitomycin C (MMC) in silkworms, but little is known about the requirement for repair of other types of DNA damage. Here we report that silkworm cells deficient for FA proteins FancD2 and FancM exhibit normal sensitivities to hydroxyurea (HU) and camptothecin (CPT), although FancM-dependent FancD2 monoubiquitination is induced upon these treatments. Similar results were observed in cells depleted for Rmi1 and Mhf1, which interact with the FancM protein. We also found that Rad51-knockdown cells exhibited normal sensitivity to HU despite induction of double-strand breaks by HU treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 21, 3 November 2014, Pages 3959-3963
نویسندگان
, , , , ,