کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10870750 | 1074019 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
miR-181a mediates metabolic shift in colon cancer cells via the PTEN/AKT pathway
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: miR-181a mediates metabolic shift in colon cancer cells via the PTEN/AKT pathway miR-181a mediates metabolic shift in colon cancer cells via the PTEN/AKT pathway](/preview/png/10870750.png)
چکیده انگلیسی
Cancer cell metabolism is often characterized by a shift from an oxidative to a glycolytic bioenergetics pathway, a phenomenon known as the warburg effect. Whether the deregulation of miRNAs contributes to the warburg effect remains largely unknown. Here we show that miR-181a expression is increased and thus induces a metabolic shift in colon cancer cells. miR-181a performs this function by inhibiting the expression of PTEN, leading to an increase of phosphorylated AKT which triggers metabolic shift. The increase of lactate production induced by miR-181a results in the rapid growth of cancer cells. These results identify miR-181a as a molecular switch involved in the orchestration of the warburg effect in colon cancer cells via the PTEN/AKT pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 9, 2 May 2014, Pages 1773-1779
Journal: FEBS Letters - Volume 588, Issue 9, 2 May 2014, Pages 1773-1779
نویسندگان
Zhonghua Wei, Long Cui, Zubing Mei, Min Liu, Daoxiang Zhang,