کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870834 1074023 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment
چکیده انگلیسی
Death receptor 6 (DR6) is a member of the death domain-containing receptors that belong to the TNFR superfamily. To date, the ligand for DR6 is still not clearly defined. Here, we developed a functional agonist monoclonal antibody (DQM3) against DR6, which bound to the first cysteine-rich domain. Importantly, DR6 signaling could be clearly activated by DQM3, which was dependent on its intracellular death domain. In addition, we demonstrated that the association between DR6 and TRADD was enhanced upon DQM3 stimulation and TRADD was involved in DR6-induced signaling activation. Taken together, our findings provide new insight into a novel mechanism by which DR6 induces downstream signaling in response to an agonist antibody.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 3, 31 January 2014, Pages 401-407
نویسندگان
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