کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870887 1074025 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
miR-150 promotes the proliferation of lung cancer cells by targeting P53
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
miR-150 promotes the proliferation of lung cancer cells by targeting P53
چکیده انگلیسی
Lung cancer is one of the most common causes for cancer-related death. Previous studies suggested that uncontrolled cell proliferation induced by activation of pro-cancer genes or inhibition of cancer suppressor genes plays an important role in the pathogenesis of lung cancer. Here, we demonstrate that miR-150 is aberrantly upregulated in lung cancer tissue and negatively correlates with the expression of the proapoptotic gene p53 but not EGR2. We show that miR-150 specifically targets the 3′-UTR of p53 and regulates its expression. Inhibition of miR-150 effectively delays cell proliferation and promotes apoptosis, accompanied by increased p53 protein expression. Our data reveals the mechanisms underlying miR-150 regulated lung cancer pathogenesis, which might be beneficial for lung cancer therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 587, Issue 15, 2 August 2013, Pages 2346-2351
نویسندگان
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