Presynaptic kainate receptor-mediated facilitation of glutamate release involves Ca2+-calmodulin and PKA in cerebrocortical synaptosomes

► Kainate receptor activation mediates a facilitation of glutamate release in cerebrocortical synaptosomes. ► This facilitation of glutamate release involves the AC/cAMP/PKA pathway. ► AC is activated by Ca2+ from intraterminal stores.