Mitochondrial fragmentation caused by phenanthroline promotes mitophagy

► Phenanthroline induces mitochondrial fragmentation and dysfunctions. ► Phenanthroline induces ATG5 dependent autophagy. ► Phenanthroline induces loss of mitochondrial mass and mitophagy. ► Depletion of Drp1 and ATG5 suppresses Phen-induced loss of mitochondrial mass.