Endothelin-1 induces hypoxia inducible factor 1α expression in pulmonary artery smooth muscle cells

► Endothelin-1 posttranscriptionally increases HIF1α expression by suppressing proteasome-dependent HIF1α degradation. ► Endothelin-1 stimulates calcineurin activation through endothelin receptor A. ► Calcineurin mediates endothelin-1-induced RACK1 de-phosphorylation. ► RACK1 particularly mediates proteasome-dependent HIF1α degradation.