Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells

► Amadori-PE, a lipid glycation product, elicits cellular telomerase activity in a time- and dose-dependent manner. ► Amadori-PE modulates telomerase by up-regulating hTERT mRNA expression through induction of c-myc expression. ► Amadori-PE may participate not only in the pathogenesis of diabetic complications but also in tumor progression.