Suppression of metastases of small cell lung cancer cells in mice by a peptidic CXCR4 inhibitor TF14016

► Anti-metastatic efficacy of TF14016, a CXCR4 inhibitor, on SCLC was examined. TF14016 treatment significantly suppressed pulmonary metastases of SCLC cells in mice. ► VEGF expression in metastasized SCLC cells was suppressed by TF14016-treatment. ► CD31-positive microvessels in metastatic foci were reduced by TF14016 treatment. ► CXCR4 could be a target for anti-metastatic and anti-angiogenic therapy in SCLC.