Direct reprogramming of terminally differentiated B cells into erythroid lineage

► We tried reprogramming terminally differentiated B cells into erythroid lineage. ► We introduced various transcription factors into activated B cells by retrovirus. ► Erythroid conversion of B cells was achieved by introducing GATA-1, SCL and C/EBPα. ► Converted cells retained rearrangement of IgH gene, confirming their B cell origin. ► Converted cells presented erythroid morphology and expressed erythrocyte genes.