G/A polymorphism in intronic sequence affects the processing of MAO-B gene in patients with Parkinson disease

► Elevated levels of MAO B protein expression detected in PD patient blood fraction.. ► Intron 13 containing “A” allele is removed from pre-mRNA more efficiently. ► SR proteins interact more efficiently with pre-mRNA sequence containing A allele. ► Stronger SR protein interacion influences intron removal from MAO-B pre-mRNA.