Inhibition of NF-κB by MG132 through ER stress-mediated induction of LAP and LIP

► MG132 suppresses NF-κB through induction of ER stress. ► Through ER stress, MG132 up-regulates C/EBPβ mRNA and causes sustained accumulation of LAP and LIP. ► LAP and LIP mediates inhibition of NF-κB by MG132.