The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast

► Human Bax physically interacts with mammalian and yeast Tom22. ► A peptide corresponding to the receptor domain of Tom22 stimulates Bax translocation. ► This peptide favors an inactive conformation of Bax. ► This peptide favors a dimeric form of Bax at the expense of the oligomeric form.