کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10871595 1074062 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Generating pluripotent stem cells: Differential epigenetic changes during cellular reprogramming
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Generating pluripotent stem cells: Differential epigenetic changes during cellular reprogramming
چکیده انگلیسی
Pluripotent stem cells hold enomous potential for therapuetic applications in tissue replacement therapy. Reprogramming somatic cells from a patient donor to generate pluripotent stem cells involves both ethical concerns inherent in the use of embryonic and oocyte-derived stem cells, as well as issues of histocompatibility. Among the various pluripotent stem cells, induced pluripotent stem cells (iPSC)-derived by ectopic expression of four reprogramming factors in donor somatic cells-are superior in terms of ethical use, histocompatibility, and derivation method. However, iPSC also show genetic and epigenetic differences that limit their differentiation potential, functionality, safety, and potential clinical utility. Here, we discuss the unique characteristics of iPSC and approaches that are being taken to overcome these limitations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 586, Issue 18, 31 August 2012, Pages 2874-2881
نویسندگان
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