کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10871614 1074064 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The layout of a bacterial genome
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The layout of a bacterial genome
چکیده انگلیسی
Recently the mismatch between our newly acquired capacity to synthetize DNA at genome scale, and our low capacity to design ab initio a functional genome has become conspicuous. This essay gathers a variety of constraints that globally shape natural genomes, with a focus on eubacteria. These constraints originate from chromosome replication (leading/lagging strand asymmetry; gene dosage gradient from origin to terminus; collisions with the transcription complexes), from biased codon usage, from noise control in gene expression, and from genome layout for co-functional genes. On the basis of this analysis, lessons are drawn for full genome design.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 586, Issue 15, 16 July 2012, Pages 2043-2048
نویسندگان
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