Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation

► Phosphodiesterase PDE8A1 is phosphorylated on serine 359 by protein kinase-A. ► Phosphorylation of PDE8A1 by protein kinase-A activates the enzyme. ► PDE8 activity protects it from PKA phosphorylation under basal cyclic-AMP conditions.