Keywords: α-CGRP; alpha-calcitonin gene related peptide; Ang; angiopoietin; AE2; anion exchanger 2; ADP; adenosine diphosphate; ADPKD; autosomal dominant polycystic kidney disease; ATP; adenosine triphosphate; ASBT; sodium-dependent bile acid transporter; AQP; aqu
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Keywords: AC; adenylate cyclase; ADHD; attention deficit hyperactivity disorder; ACC; anterior cingulate cortex; ALS; amyotrophic lateral sclerosis; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATP; adenosine triphosphate; BBB; blood-brain barrier;
Keywords: 5-HT; 5-hydroxytryptamine; 5-HTT; 5-hydroxytryptamine transporter; AC; adenylyl cyclase; AD; Alzheimer's disease; Akt; protein kinase B; AMPAR; α-amino-3-hydroxy-5-mthhyl-4-isoxazolepropionic acid receptor; apCAM; Aplysia cell adhesion molecules; ASD;
Keywords: Asherman's syndrome; intrauterine adhesions; D&C; dilatation and curettage; EPAC; Early Pregnancy Assessment Clinic; IUA; intrauterine adhesions; RPOC; retained products of conception;
Keywords: GLUT; Glucose transporter; T1DM; Type-1 diabetes mellitus; T2DM; Type-2 diabetes mellitus; PKB/Akt; protein kinase B; GSK-3; glycogen synthase kinase-3; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator-1α; FOXO; forkhead box O; VLDL;
Keywords: AcTub; acetylated α-tubulin; BBS; Bardet-Biedl syndrome; βARKct; beta-adrenergic receptor kinase carboxyl-terminus; cAMP; cyclic AMP; C-tail; C-terminal tail; Epac; exchange protein directly activated by cAMP; ERK; extracellular signal-regulated kinas
Keywords: Calcium signaling; Salivary gland; Purinergic receptor; Epac; cAMP; Parotid; Exocytosis; Crosstalk;
Keywords: GluOC; uncarboxylated osteocalcin; GlaOC; γ-carboxylated osteocalcin; PKA; protein kinase A; ERK; extracellular signal-regulated kinase; PPAR; peroxisome proliferator-activated receptor; GLP-1; glucagon-like peptide-1; gWAT; gonadal white adipose tissue;
Keywords: Cox; cyclooxygenase; CREB; cAMP response element binding protein; CACS; cancer-related anorexia and cachexia syndrome; CRP; C-reactive protein; COPD; chronic obstructive pulmonary disease; DAG; des-acyl ghrelin; ERK; extracellular signal-regulated kinase;
Keywords: AC; adenylyl cyclase; AKT; protein kinase B; AMPK; AMP-activated protein kinase; AnR; androgen receptor; ARF6; ADP ribosylation factor 6; CaMK; Ca2+-calmodulin dependent kinase; CaMKK; CaMK kinase; cAMP; cyclic adenosine 3â²,5â²-monophosphate; CDK5; cyc
Keywords: Prostate cancer; Radioresistance; cAMP; EPAC; ERK1/2
Keywords: AC; adenylyl cyclase; CCK; cholecystokinin; CFTR; cystic fibrosis transmembrane regulator; CREBs; cAMP response element binding proteins; EGF; epidermal growth factor; Epac; Exchange protein directly activated by cAMP; GDP; guanosine diphosphate; GEF; gua
Keywords: BiFC; bimolecular fluorescence complementation; cAMP; cyclic adenosine monophosphate; EPAC; exchange protein directly activated by cAMP; F26P2; fructose 2,6-bisphosphate; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GK; glucokinase; GKRP; glucokinase
Keywords: Dendritic cell; microbiota; pattern recognition receptors; histamine; histamine receptors; nuclear factor κB; cyclic AMP; Lactobacillus rhamnosus; AP-1; Activator protein 1; cAMP; Cyclic AMP; DC; Dendritic cell; Epac; Exchange protein directly activated
Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings
Keywords: BRET; bioluminescence resonance energy transfer; cAMP; cyclic adenosine monophosphate; Dmt; 2,6-dimethyltyrosine; DOP; δ-opioid receptor; EC50; half maximal effective concentration; EPAC; exchange protein directly activated by cAMP; GPI; guinea pig ileum
Phoenixin-14 stimulates differentiation of 3T3-L1 preadipocytes via cAMP/Epac-dependent mechanism
Keywords: AKT; RAC-alpha serine/threonine-protein kinase; BMI; body mass index; BrdU; 5âbromoâ2â²âdeoxyuridine; cAMP; cyclic adenosine monophosphate; C/ebpβ; CCAAT/enhancer-binding protein beta; Epac; exchange protein directly activated by cAMP; Fabp4; fatt
Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2Â + handling in cardiomyocytes
Keywords: Epac; Sarcoplasmic reticulum calcium handling; CaMKII-dependent phosphorylations;
An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation
Keywords: Tri-agonist; Signaling cascade; Pancreatic islets; Insulin secretion; G proteins; TRP channels; AC; Adenylyl cyclase; cAMP; Cyclic adenosine monophosphate; ECL; Extracellular loop; EPAC; Exchange protein directly activated by cAMP; FCS; Fetal calf serum;
Prostaglandin E2 as a Regulator of Immunity to Pathogens
Keywords: AA; Arachidonic Acid; BMT; Bone marrow transplant; cAMP; Cyclic adenosine monophosphate; COX; Cyclooxygenase; EP; E-type prostanoid; EPAC; Exchange protein directly activated by cAMP; ERK; Extracellular signal-regulated kinases; GSK-3; Glycogen synthase k
Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells
Keywords: AC; adenylyl cyclase; 2-APB; 2-aminoethoxyphenylborane; ASM; airway smooth muscle; cAMP; 3',5'-cyclic AMP; COPD; chronic obstructive pulmonary disease; [Ca2+]i; intracellular free Ca2+ concentration; DMSO; dimethyl sulfoxide; EC50 (IC50); half-maximally e
Sustained β-AR stimulation induces synthesis and secretion of growth factors in cardiac myocytes that affect on cardiac fibroblast activation
Keywords: α-SMA; α-smooth muscle actin; AC; adenylate cyclase; 6-Bnz-cAMP; N6-benzoyladenosine-3â²,5â²-cyclic monophosphate; cAMP; cyclic adenosine monophosphate; COL1A1; collagen type I alpha1; COL1A2; collagen type I alpha2; CTGF; connective tissue growth fac
Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes
Keywords: Phospholipase C; Cardiac hypertrophy; Phosphatidylinositol 4-phosphate; Phosphodiesterase; Epac; Cyclic AMP; A kinase anchoring protein; Golgi apparatus;
On the G protein-coupling selectivity of the native A2B adenosine receptor
Keywords: BAY60-6583; 2-[[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CE3F4; 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde; CGS21680; 2-[p-(2-carboxyethy
Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs)
Keywords: Exchange proteins directly activated by cAMP; EPAC; Antagonist; Molecular docking;
Host Epac1 is required for cAMP-mediated invasion by Trypanosoma cruzi
Keywords: Trypanosoma cruzi; Invasion; cAMP; Epac; PKA;
Exchange proteins directly activated by cAMP induce the proliferation of rat anterior pituitary GH3 cells via the activation of extracellular signal-regulated kinase
Keywords: Epac; B-Raf; ERK; Proliferation; Pituitary cells;
Regulation of IP3 receptors by cyclic AMP
Keywords: AC; adenylyl cyclase; EPAC; exchange protein activated by cAMP; IP3; inositol 1,4,5-trisphosphate; IP3R; IP3 receptor; IRAG; IP3R-associated cGMP kinase substrate; IRBIT; IP3R-binding protein released by IP3; PKA; protein kinase A (cAMP-dependent protein
Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets
Keywords: EPAC; cAMP; Agonist; Antagonist; Modulator;
Divergent cAMP signaling differentially regulates serotonin-induced spinal motor plasticity
Keywords: Motor neuron; Phrenic; Spinal cord; Respiratory plasticity; 5-HT7 receptor; 5-HT2 receptor; Exchange protein activated by cAMP; Protein kinase A; EPAC; PKA;
Review articleThe role of cAMP and its downstream targets in neurite growth in the adult nervous system
Keywords: SCI; spinal cord injury; EPAC; exchange protein activated by cAMP; PKA; EPAC; EPAC2; Spinal cord injury; Molecular signalling;
β-Adrenergic induced SR Ca2 + leak is mediated by an Epac-NOS pathway
Keywords: Excitation-contraction coupling; Sarcoplasmic reticulum; Ryanodine receptor; Calcium calmodulin-dependent protein kinase; Epac; Nitric oxide synthase;
Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway
Keywords: Epac; exchange protein activated by cyclic AMP; PKC; protein kinase C; LVEF; left ventricular ejection fraction; TNF; tumor necrosis factor; IL; interleukin; Jak-STAT; janus kinase-signal transducers and activators of transcription; SOCS3; suppressor of c
ReviewThe dynamic plasticity of insulin production in β-cells
Keywords: T2DM; Insulin production; β-cell rest; ATF6; Activating Transcription Factor 6; CHOP; CCAAT/Enhancer-Binding Homologous Protein; EPAC; Exchange Factor Directly Activated by cAMP; EROβ1; ER-resident oxidoreductase β1; GIP; Gastric Inhibitory Polypeptide
Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK
Keywords: SRT1720; Phosphodiesterases; cAMP; AMPK; Sirt1; Epac; Type 2 diabetes; Obesity; Aging; Mitochondria;
cAMP/PKA enhances interleukin-1β-induced interleukin-6 synthesis through STAT3 in glial cells
Keywords: 8-bromo cAMP; adenosine-3â²,5â²-cyclic monophosphate, 8-bromo-, sodium salt; CMI; 4-cyano-3-methylisoquinoline; CNS; central nervous system; DMEM; Dulbecco's modified Eagle's medium; EPAC; exchange proteins directly activated by cAMP; ELISA; enzyme-link
Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction
Keywords: Adenylyl cyclase; Epac; Catecholamine; Heart failure; Arrhythmia;
Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness
Keywords: Neutrophil; β2-agonist; cyclic AMP; exchange protein directly activated by cyclic AMP; hospital-acquired infection; AKAP; A kinase anchoring protein; BALTI-2; Beta Agonist Lung Injury Trial-2; cAMP; Cyclic AMP; EPAC; Exchange protein directly activated b
L-DOPA modulates cell viability through the ERK-c-Jun system in PC12 and dopaminergic neuronal cells
Keywords: L-DOPA; Epac; ERK1/2; c-Jun; PC12 cells; Rat model of Parkinson's disease
Effects of (â)-sesamin on motor and memory deficits in an MPTP-lesioned mouse model of Parkinson's disease treated with l-DOPA
Keywords: 6-OHDA; 6-hydroxydopamine; CREB; cyclic AMP-response element binding protein cyclic AMP; DOPAC; 3,4-dihydroxyphenylacetic acid; Epac; exchange protein activation by cAMP; ERK; extracellular signal-regulated kinase; HVA; homovanillic acid; JNK; c-Jun N-ter
Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity
Keywords: ANOVA; analysis of variance; ATF-1; activating transcription factor-1; CCL-2; chemokine ligand 2; CCL-8; chemokine ligand 8; CCL-18; chemokine ligand 18; CCR-1; chemokine receptor 1; CRBN; cereblon; CRE; cAMP responsive element; CREB; cAMP responsive elem
Comprehensive analysis of chemokine-induced cAMP-inhibitory responses using a real-time luminescent biosensor
Keywords: AC; adenylate cyclase; APC; allophycocyanin; AUC; area under curve; CHK; chemokine; EPAC; exchange protein directly activated by cAMP; FSK; forskolin; HEKgloCX3CR1; HEK293 clone stably expressing CX3CR1 and the GloSensor⢠F-22; PDE; phosphodiesterase; P
Type II PKAs are anchored to mature insulin secretory granules in INS-1 β-cells and required for cAMP-dependent potentiation of exocytosis
Keywords: Pancreatic; Endocrine; Insulin; Exocytosis; Potentiation; Protein kinase-A; cAMP; Compartmentalization; AKAP; A-Kinase anchoring protein; Epac; Exchange proteins directly activated by cAMP; GEF; Guanine nucleotide exchange factor; GLP-1; Glucagon-like pep
Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1
Keywords: A2AR; adenosine A2A receptor; AP-1; activator protein 1; BLC; B-lymphocyte chemoattractant; BMDM; bone marrow derived macrophage; CREB; cAMP response element-binding protein; DUSP1; dual specific phosphatase; Epac; exchange protein activated by cAMP; ERK;
The signaling module cAMP/Epac/Rap1/PLCε/IP3 mobilizes acrosomal calcium during sperm exocytosis
Keywords: 2-APB; 2-aminoethoxydiphenylborate; AR; acrosome reaction; 6-Bnz-cAMP; N6-benzoyladenosine-3â²,5â²-cyclic monophosphate; cAMP; cyclic adenosine monophosphate; Epac; guanine nucleotide exchange factor activated by cAMP; GEF; guanine nucleotide exchange f
The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects
Keywords: NO; nitric oxide; NO2; dioxide radical; O2; superoxide; ONO2â; Â peroxynitrite; 15-dPGJ2; 15-deoxy-Î12,14-prostaglandin J2; AA; arachidonic acid; ADH; alcohol dehydrogenase; AF-1; ligand-independent activation function; AF-2; ligand-dependent activatio
PI3K is involved in P2Y receptor-regulated cAMP /Epac/Kv channel signaling pathway in pancreatic β cells
Keywords: P2Y purinergic receptor; Voltage-dependent potassium channels; Epac; Insulin secretion; Phosphatidylinositide 3-kinase;
Translating Basic Research Into Clinical PracticeProstanoids in Asthma and COPD: Actions, Dysregulation, and Therapeutic Opportunities
Keywords: cAMP; cyclic adenosine monophosphate; COX; cyclooxygenase; EP; E prostanoid receptor; Epac; exchange protein activated by cyclic adenosine monophosphate; GPCR; G protein-coupled receptor; IP; I prostanoid receptor; PG; prostaglandin; PKA; protein kinase A
cAMP-mediated secretion of brain-derived neurotrophic factor in developing airway smooth muscle
Keywords: Lung; Development; Hyperoxia; Neurotrophin; Cyclic nucleotide; Epac;
VIP induces NF-κB1-nuclear localisation through different signalling pathways in human tumour and non-tumour prostate cells
Keywords: VIP; vasoactive intestinal peptide; EPAC; cAMP/exchange protein directly activated by cAMP; NF-κB; nuclear factor-κB; PKA; cAMP-dependent protein kinase; ERK; extracellular-signal regulated kinase; PI3-K; phosphoinositide 3-kinase; GEF; PKA-independent
Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells
Keywords: EPAC; exchange protein directly activated by cAMP; ROCK; RhoA activated Protein Kinase; PKA; protein kinase A; HUVEC; human umbilical vein endothelial cells; GEF; guanine exchange factor; ERM; ezrin-radixin-moesin family; FERM; 4.1 ezrin-radixin-m