کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8535808 | 1560535 | 2018 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sustained β-AR stimulation induces synthesis and secretion of growth factors in cardiac myocytes that affect on cardiac fibroblast activation
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کلمات کلیدی
DDAα-SMAPKICol1a2COL1A1CTGFEpacpKaECM2′,5′-dideoxyadenosinecAMP - cAMPCyclic adenosine monophosphate - آدنوزین مونوفسفات Cyclicadenylate cyclase - آدنیلات سیکلاسα-smooth muscle actin - اکتین عضله آلفا صافISO - ایزوisoproterenol - ایزوپروترنولparacrine factor - عامل پاراکرینVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Connective tissue growth factor - فاکتور رشد بافت همبندCardiac fibroblast - فیبروبلاست قلبExtracellular matrix - ماتریکس خارج سلولیCardiac myocyte - میوسیت قلبیExchange protein directly activated by cAMP - پروتئین تبادل شده به طور مستقیم توسط cAMP فعال می شودprotein kinase A - پروتئین کیناز Aβ-Adrenergic receptor - گیرنده β-adrenergic
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Sustained β-AR stimulation induces synthesis and secretion of growth factors in cardiac myocytes that affect on cardiac fibroblast activation Sustained β-AR stimulation induces synthesis and secretion of growth factors in cardiac myocytes that affect on cardiac fibroblast activation](/preview/png/8535808.png)
چکیده انگلیسی
Paracrine factors, including growth factors and cytokines, released from cardiac myocytes following β-adrenergic receptor (β-AR) stimulation regulate cardiac fibroblasts. Activated cardiac fibroblasts have the ability to increase collagen synthesis, cell proliferation and myofibroblast differentiation, leading to cardiac fibrosis. However, it is unknown which β-AR subtypes and signaling pathways mediate the upregulation of paracrine factors in cardiac myocytes. In this study, we demonstrated that sustained stimulation of β-ARs significantly induced synthesis and secretion of growth factors, including connective tissue growth factor (CTGF) and vascular endothelial growth factor (VEGF), via the cAMP-dependent and protein kinase A (PKA)-dependent pathways. In addition, isoproterenol (ISO)-mediated synthesis and secretion of CTGF and VEGF through the β1-AR and β2-AR subtypes. Paracrine factors released by cardiac myocytes following sustained β-AR stimulation are necessary for the induction of cell proliferation and synthesis of collagen I, collagen III and α-smooth muscle actin (α-SMA) in cardiac fibroblasts, confirming that β-AR overstimulation of cardiac myocytes induces cardiac fibrosis by releasing several paracrine factors. These effects can be antagonized by β-blockers, including atenolol, metoprolol, and propranolol. Thus, the use of β-blockers may have beneficial effects on the treatment of myocardial fibrosis in patients with heart failure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 193, 15 January 2018, Pages 257-269
Journal: Life Sciences - Volume 193, 15 January 2018, Pages 257-269
نویسندگان
Narawat Nuamnaichati, Vilasinee Hirunpanich Sato, Primchanien Moongkarndi, Warisara Parichatikanond, Supachoke Mangmool,