کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2550499 1560576 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Noradrenaline microinjected into the dorsal periaqueductal gray matter causes anxiolytic-like effects in rats tested in the elevated T-maze
ترجمه فارسی عنوان
میکروتزریق نورآدرنالین در داخل ماده خاکستری پریاکتونیک پشتی، اثرات مشابه آنکسیولیتیک را در موش های آزمایش شده در T-labyrinth افزایش می دهد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

AimsThe dorsal periaqueductal gray matter (dPAG) is involved in the integration of behavioral and cardiovascular responses caused by fear and anxiety situations. Some studies suggest an involvement of noradrenergic neurotransmission in the dPAG in anxiety modulation, however, there is no evidence about its role in panic attacks. The goal of this work was to study the effect of NA microinjection in dPAG in rats submitted to the elevated T-maze (ETM).Materials and methodsMale Wistar had a cannula implanted in the PAG where it was injected NA in the doses of 1, 3, 15, 45 nmol/50 nl or artificial cerebrospinal fluid previous the ETM test.Key findings.NA intra-dPAG decreased inhibitory avoidance behavior in the ETM without changing escape, indicating only an anxiolytic-like effect. Furthermore, the microinjection of NA did not change the general exploratory activity of the animals submitted to the open field test, suggesting that the anxiolytic-like effect is not due to an increase in exploratory activity.SignificanceThe results indicate an involvement of noradrenergic neurotransmission in the dPAG in defensive reactions associated with generalized anxiety, but not as main mechanisms for the panic, in rats submitted to the elevated T-maze providing support for other research aimed at improving the treatment of generalized anxiety.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 152, 1 May 2016, Pages 94–98
نویسندگان
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