Inducing phase-locking and chaos in cellular oscillators by modulating the driving stimuli

► Model the response of transcription factor NF-kB to external signals. ► Synchronize oscillations in NF-kB with an oscillating cytokine signal. ► Synchronization leads to “Arnold tongue” diagram. ► External stimulus may cause a chaotic response in NF-kB. ► Propose a way to control the immune response and DNA repair in a cell.