p53 regulation by ubiquitin

► The ubiquitination pathway is a highly dynamic and coordinated process. ► The p53 tumor suppressor and several factors in the pathway are regulated by ubiquitin as well as ubiquitin-like proteins. ► Ubiquitination of p53 leads to both 26S proteosome-dependent and independent effects. ► Deubiquitination enzymes can specifically remove ubiquitin moieties from p53 or other factors in the pathway.