کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10871770 | 1074080 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thymus, innate immunity and autoimmune arthritis: Interplay of gene and environment
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کلمات کلیدی
TregZAP-70T cell selectionAutoimmune arthritis - آرتروز اتوایمیونRheumatoid arthritis - آرتریتروماتوئیدAnti-cyclic citrullinated peptide antibody - آنتی بادی پپتید سیترولاید ضد سایکلیInnate immunity - ایمنی ذاتیRegulatory T cell - سلول T تنظیم کنندهRegulatory T cells - سلولهای تی تنظیمکنندهTCR signaling - سیگنالینگ TCRrheumatoid factor - عامل روماتوئیدAnimal model - مدل حیوانی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Thymus, innate immunity and autoimmune arthritis: Interplay of gene and environment Thymus, innate immunity and autoimmune arthritis: Interplay of gene and environment](/preview/png/10871770.png)
چکیده انگلیسی
A hypomorphic mutation of the gene encoding zeta-associated protein-70 (ZAP-70), a signaling molecule in T cells, produces autoimmune arthritis in mice under a microbially conventional condition but not in a clean environment. The genetic anomaly alters thymic selection of self-reactive T cells as well as natural regulatory T cells and their respective functions. Highly self-reactive polyclonal T cells, including arthritogenic ones, thus produced by the thymus strongly recognize self-antigens presented by antigen-presenting cells, stimulate them to up-regulate co-stimulatory molecules and secrete cytokines that drive naïve self-reactive T cells to differentiate into autoimmune effector Th17 cells. Administration of microbial products and activation of complement can facilitate the differentiation, evoking clinically overt arthritis in a microbially clean environment. Furthermore, mutation-dependent graded attenuation of T cell receptor signaling alters disease phenotypes and the dependency of disease occurrence on the environment. These findings provide a model of how genetic and environmental factors, in association, cause autoimmune diseases such as rheumatoid arthritis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 585, Issue 23, 1 December 2011, Pages 3633-3639
Journal: FEBS Letters - Volume 585, Issue 23, 1 December 2011, Pages 3633-3639
نویسندگان
Shimon Sakaguchi, Satoshi Tanaka, Atsushi Tanaka, Yoshinaga Ito, Shinji Maeda, Noriko Sakaguchi, Motomu Hashimoto,