کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10871834 1074087 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Defending the end zone: Studying the players involved in protecting chromosome ends
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Defending the end zone: Studying the players involved in protecting chromosome ends
چکیده انگلیسی
The linear nature of eukaryotic chromosomes leaves natural DNA ends susceptible to triggering DNA damage responses. Telomeres are specialized nucleoprotein structures that comprise the “end zone” of chromosomes. Besides having specialized sequences and structures, there are six resident proteins at telomeres that play prominent roles in protecting chromosome ends. In this review, we discuss this team of proteins, termed shelterin, and how it is involved in regulating DNA damage signaling, repair and replication at telomeres.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 17, 10 September 2010, Pages 3773-3778
نویسندگان
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