کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10871837 1074087 2010 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers
چکیده انگلیسی
Alternative Lengthening of Telomeres (ALT) activity can be deduced from the presence of telomere length maintenance in the absence of telomerase activity. More convenient assays for ALT utilize phenotypic markers of ALT activity, but only a few of these assays are potentially definitive. Here we assess each of the current ALT assays and their implications for understanding the ALT mechanism. We also review the clinical situations where availability of an ALT activity assay would be advantageous. The prevalence of ALT ranges from 25% to 60% in sarcomas and 5% to 15% in carcinomas. Patients with many of these types of ALT[+] tumors have a poor prognosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 17, 10 September 2010, Pages 3800-3811
نویسندگان
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