Protein kinase D regulates the human cardiac L-type voltage-gated calcium channel through serine 1884

► Protein kinase D (PKD) regulates the cardiac L-type voltage-gated calcium channel. ► We mutate the putative targets (S1884, S1930) of PKD on human cardiac L-type channel. ► We measure expression, phosphorylation and activity of L-type channel WT and mutants. ► S1884 is the functional targets of PKD on the human cardiac L-type channel.