کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10871966 1074094 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functional argument for the existence of an avian nitric oxide synthase in muscle mitochondria: Effect of cold acclimation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Functional argument for the existence of an avian nitric oxide synthase in muscle mitochondria: Effect of cold acclimation
چکیده انگلیسی
We report the first evidence of a mitochondrial NO synthase (mtNOS) in bird skeletal muscle. In vitro, mtNOS activity stimulated by l-arginine reduced intermyofibrillar mitochondrial oxygen uptake and ATP synthesis rates, stimulated endogenous H2O2 generation, but had no effect on oxidative phosphorylation efficiency. Arginine-induced effects were fully reversed by l-NAME, a known NOS inhibitor. When ducklings were cold exposed for 4 weeks, muscle mitochondria displayed an increased state 3 respiration, a reduced H2O2 generation but no significant alteration in mtNOS activity. We conclude that mtNOS is expressed in avian skeletal muscle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 585, Issue 1, 3 January 2011, Pages 173-177
نویسندگان
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